Product Description: Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.
Applications: Metabolism-sugar/lipid metabolism
Formula: C19H21ClN2O3S
Citations: Inflammation. 2020 Apr;43(2):568-578./Int J Oncol. 2018 Aug;53(2):551-566./J Diabetes Res. 2019 Feb 3;2019:5245063./Mol Med Rep. 2024 Nov;30(5):209./Mol Med Rep. 2019 Jan;19(1):400-406./Acta Pharmacol Sin. 2021 Jan;42(1):160-170./Adv Sci (Weinh). 2024 Dec 25:e2407134./Adv Sci (Weinh). 2024 Oct 7:e2401931./Am J Physiol Heart Circ Physiol. 2021 Apr 9./Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F137-F151./Biochem Eng J. 2021, 108104./BMC Complement Med Ther. 2022 Jul 1;22(1):176./Br J Pharmacol. 2021 Jun;178(11):2305-2323./Cancer Res. 2022 Apr 15;82(8):1503-1517./Cell Metab. 2021 Mar 2;33(3):581-597.e9./Cell Stem Cell. 2022 Sep 1;29(9):1366-1381.e9./Food Chem Toxicol. 2021 Apr 6;112183./Gut Microbes. 2022, 14(1): 2139978./Heliyon. 2023 Apr 1./Immunology. 2023 Jan 28./Immunopharmacol Immunotoxicol. 2021 Aug 27;1-9./J Adv Res. 2024 Sep 29:S2090-1232(24)00427-2./J Ethnopharmacol. 2024 Nov 29:340:119128./J Steroid Biochem Mol Biol. 2023 Feb 1;229:106265./Med Sci Monit. 2019 Nov 13;25:8544-8553./Nutr Metab (Lond). 2019 Mar 5;16:17. /Oxid Med Cell Longev. 2022./Res Sq. 2024 Jul 12./Research Square Preprint. 2021 Mar./SSRN. 2023 May 30./Tunku Abdul Rahman University. 2024 Mar 11.
References: [1]Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose leve/[2]Puddu A, et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177(1-3):79-84./[3]Kubota N, et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem. 2006 Mar 31;281(13):8748-55./[4]Elrashidy RA, et al. Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther. 2012 Sep;17(3):324-33.
CAS Number: 112529-15-4
Molecular Weight: 392.90
Compound Purity: 99.97
Research Area: Cancer; Metabolic Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Ferroptosis;PPAR
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