PLX51107, CAS 1627929-55-8

Product Description: PLX51107 is a potent and selective BET inhibitor, with Kds of 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1, and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively; PLX51107 also interacts with the bromodomains of CBP and EP300 (Kd, in the 100 nM range).

Applications: Cancer-programmed cell death

Formula: C26H22N4O3

References: [1]Ozer HG, et al. BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discov. 2018 Apr;8(4):458-477.

CAS Number: 1627929-55-8

Molecular Weight: 438.48

Compound Purity: 99.98

Research Area: Cancer

Solubility: DMSO : 75 mg/mL (ultrasonic)

Target: Epigenetic Reader Domain

• SKU: MEXHY-111422-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-111422-25
• Package Unit: 25 mg
• Quantity Unit: STK