PMX 205, CAS 514814-49-4

Product Description: PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist.

Applications: COVID-19-immunoregulation

Formula: C45H62N10O6

Citations: Cell Mol Neurobiol. 2022 Aug 25./Cell Rep. 2023 Mar 15;42(3):112240./Theranostics. 2019 Oct 12;9(25):7566-7582. /Adv Sci (Weinh). 2024 Jun 5:e2400819./Cell Death Dis. 2024 Oct 5;15(10):729./Clin Immunol. 2025 Feb 19:110459./Int J Cancer. 2023 Jul 1;153(1):224-237./La Trobe University. 2022 Jan.

References: [1]Kosni NN, et al. Expression of complement C5a receptor and the viability of 4T1 tumor cells following agonist-antagonist treatment. J Cancer Res Ther. 2016 Apr-Jun;12(2):590-6./[2]Woodruff TM, et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008 Dec 15;181(12):8727-34./[3]Fonseca MI, et al. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15;183(2):1375-83.

CAS Number: 514814-49-4

Molecular Weight: 839.04

Compound Purity: 99.54

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Complement System

• SKU: MEXHY-110136-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-110136-5
• Package Unit: 5 mg
• Quantity Unit: STK