PNU-292137, CAS 326823-27-2

Product Description: PNU-292137 is an orally active, potent CDK2 inhibitor with IC50s of 37 nM and 92 nM for CDK2/cyclin A and CDK2/cyclin E, respectively. PNU-292137 makes interactions with the hydrophobic pocket at the back of the CDK2 ATP pocket. PNU-292137 efficiently inhibits tumor cell proliferation in human colon and prostate tumor cell lines. PNU-292137 exhibits antitumor activity (TGI>50%) in a mouse xenograft model[1].

Formula: C18H17N3O

References: [1]Paolo Pevarello, et al. 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding. J Med Chem. 2004 Jun 17;47(13):3367-80.

CAS Number: 326823-27-2

Molecular Weight: 291.35

Compound Purity: 99.93

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: CDK

• SKU: MEXHY-123045-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-123045-5
• Package Unit: 5 mg
• Quantity Unit: STK