PROTAC CDK9 degrader-11, CAS 3039540-19-4

Product Description: PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC degrader for CDK9 with DC50 of 1.09 nM. PROTAC CDK9 degrader-11 exhibits cytotoxicity in multi small cell lung cancer cell with IC50 of nanomolar levels. PROTAC CDK9 degrader-11 arrests cell cycle at G0/G1 phase, inhibits the cell invasion in DMS114 and DMS53 cell. PROTAC CDK9 degrader-11 exhibits antitumor efficacy in NCI-H446 xenograft mouse models[1].(Pink: ligand for target protein CDK9 ligand 3 (HY-170979); Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56 (HY-W247437))

Applications: Cancer-Kinase/protease

Formula: C39H48Cl2N10O5

References: [1]Wang Y, et al., Identification of a Potent and Selective CDK9 Degrader as a Targeted Therapeutic Option for the Treatment of Small-Cell Lung Cancer. J Med Chem. 2025 Feb 13;68(3):2528-2550.

CAS Number: 3039540-19-4

Molecular Weight: 807.77

Research Area: Cancer

Target: CDK;PROTACs

• SKU: MEXHY-170978-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170978-0
• Package Unit: Get quote
• Quantity Unit: STK