PROTAC HPK1 Degrader-1, CAS 3034182-97-0

Product Description: PROTAC HPK1 Degrader-1 (Compound B1) is a potent HPK1 degrader with DC50 value of 1.8 nM. PROTAC HPK1 Degrader-1 inhibits phosphorylation of the SLP76 protein with IC50 value of 496.1 nM. PROTAC HPK1 Degrader-1 is a bona fide HPK1-PROTAC degrader, which provided a potential tool for further HPK1 investigation in TCR signaling[1].

Applications: Cancer-Kinase/protease

Formula: C43H43N7O8

References: [1]Zeng S, et al. Discovery of highly efficient CRBN-recruiting HPK1-PROTAC as a potential chemical tool for investigation of scaffolding roles in TCR signaling. Bioorg Chem. 2024 Feb;143:107016.

CAS Number: 3034182-97-0

Molecular Weight: 785.84

Compound Purity: 99.70

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: MAP4K;PROTACs

• SKU: MEXHY-163372-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-163372-5
• Package Unit: 5 mg
• Quantity Unit: STK