PROTAC KDM3 degrader-1

Product Description: PROTAC KDM3 degrader-1 (Compound 4) is a CRBN-recruiting PROTAC designed based on the IOX1 (HY-12304) scaffold. PROTAC KDM3 degrader-1 selectively degrades the KDM3A and KDM3B proteins, thereby inhibiting the Wnt/β-catenin signaling pathway. PROTAC KDM3 degrader-1 significantly suppresses the self-renewal capacity of colorectal cancer stem cells and inhibits the growth of colorectal cancer tumors. PROTAC KDM3 degrader-1 is suitable for research on colorectal cancer (Target protein ligand (Pink): HY-12304; linker (Black): HY-22335; Conjugate of E3 ligase ligand and linker: HY-112599; E3 ligase (Blue): HY-41547)[1].

Applications: Cancer-programmed cell death

Formula: C33H37N5O10

References: [1]Zaman S U, et al. Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling[J]. RSC Medicinal Chemistry, 2024.

Molecular Weight: 663.67

Compound Purity: 99.07

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Histone Demethylase;PROTACs;Wnt;β-catenin

• SKU: MEXHY-168593-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168593-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK