PROTAC RAR Degrader-1, CAS 1351169-27-1

Product Description: PROTAC RAR degrader-1 (Compound 9) is a potent and selective RAR PROTAC Degrader consisting of apoptotic protein inhibitors (IAPs) ligands. IAPs-based degraders are also known as SNIPERs. PROTAC RAR Degrader-1 reduces RARα levels in HT1080 cells in a concentration-dependent manner but is blocked by the proteasome inhibitor MG132 (HY-13259). PROTAC RAR Degrader-1 can be used in the study of nuclear receptor-related diseases. (Pink: RAR ligand 1 (HY-111843); Black: Linker (HY-140189); Blue: IAPs Ligand (HY-B0134))[1][2].

Applications: Cancer-programmed cell death

Formula: C51H72N4O11

References: [1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176./[2]Itoh Y, et al. Design, synthesis and biological evaluation of nuclear receptor-degradation inducers. Bioorg Med Chem. 2011 Nov 15;19(22):6768-78.

CAS Number: 1351169-27-1

Molecular Weight: 917.14

Compound Purity: 97.91

Research Area: Cancer; Metabolic Disease; Neurological Disease

Solubility: DMSO : ≥ 80 mg/mL

Target: PROTACs;RAR/RXR;SNIPERs

• SKU: MEXHY-111844-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-111844-10
• Package Unit: 10 mg
• Quantity Unit: STK