PROTAC SMARCA2/4 degrader-38

Product Description: PROTAC SMARCA2/4 degrader-38 is a degrader SMARCA2/4 PROTAC (DC50: 3.0 nM and 4.0 nM respectively). PROTAC SMARCA2/4 degrader-38 promotes the ubiquitination and degradation of SMARCA2/4. PROTAC SMARCA2/4 degrader-38 blocks the G0/G1 cell cycle and induces apoptosis. PROTAC SMARCA2/4 degrader-38 can be used in acute myeloid leukemia (AML) research. (Pink: SMARCA2/4 ligand; Blue: VHL ligand (HY-112078); Black: linker; Target Protein Ligand-Linker Conjugates (HY-173343))[1].

Formula: C43H47N7O5S

References: [1]Yang T, et al. Design, synthesis and biological evaluation of 3-amino-6-(2-hydroxyphenyl)pyridazin-4-aryl derivatives as SMARCA2/4 degraders. Eur J Med Chem. 2025 Jun 5;290:117521.

Molecular Weight: 773.94

Research Area: Cancer

Target: Apoptosis;Epigenetic Reader Domain;PROTACs

• SKU: MEXHY-173333-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173333-0
• Package Unit: Get quote
• Quantity Unit: STK