PROTAC STING degrader-3

Product Description: PROTAC STING degrader-3 (Compound ST9) is a STING PROTAC degrader (DC50: 0.62 μM). PROTAC STING degrader-3 induces STING degradation via the ubiquitin-proteasome pathway. PROTAC STING degrader-3 exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling. PROTAC STING degrader-3 has renal protective effects and can be used in the study of acute kidney injury (AKI) (Pink: STING ligand (HY-47709); Blue: E3 ligase CRBN ligand (HY-41547); Black: linker)[1].

Applications: COVID-19-immunoregulation

Formula: C37H36N8O10

References: [1]Ma R, et al. Discovery of novel rigid STING PROTAC degraders as potential therapeutics for acute kidney injury. Eur J Med Chem. 2025 Jun 5;290:117539.

Molecular Weight: 752.73

Research Area: Inflammation/Immunology

Target: NF-κB;PROTACs;STING

• SKU: MEXHY-173414-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173414-0
• Package Unit: Get quote
• Quantity Unit: STK