PT109, CAS 2059104-90-2

PT109, CAS 2059104-90-2
SKU
MEXHY-167832-25
Packaging Unit
25 mg
Manufacturer
MedChemExpress

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Product Description: PT109 is a multi-kinase inhibitor. PT109 inhibits JNK (JNK1: IC50=0.143 μM; JNK2: IC50=0.831 μM; JNK3: IC50=0.285 μM) and other kinases (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM; ROCK2: IC50=34 μM) and plays an important role in anti-inflammation, anti-oxidation, neurogenesis, synaptogenesis, etc. In addition, PT109 also reprograms glioblastoma multiforme (GBM) into oligodendrocytes through the PTBP1/PKM1/2 pathway and changes the metabolic pattern of GBM, exerting anti-glioma activity[1][2].

Applications: COVID-19-anti-virus

Formula: C23H31N3OS2

References: [1]Chen Q, et al. Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo[J]. European Journal of Pharmacology, 2020, 883: 173361./[2]Yang Y, et al. PT109, a novel multi-kinase inhibitor suppresses glioblastoma multiforme through cell reprogramming: Involvement of PTBP1/PKM1/2 pathway[J]. European Journal of Pharmacology, 2022, 920: 174837.

CAS Number: 2059104-90-2

Molecular Weight: 429.64

Research Area: Cancer; Inflammation/Immunology; Neurological Disease

Target: JNK;ROCK;SGK
More Information
SKU MEXHY-167832-25
Manufacturer MedChemExpress
Manufacturer SKU HY-167832-25
Package Unit 25 mg
Quantity Unit STK
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