Product Description: PROTAC PIN1 degrader-2 (1) is a PROTAC-based PIN1 degrader (Pink: PIN1 ligand HY-171442, Blue: cereblon ligand Thalidomide (HY-14658), Black: linker HY-W014883). PROTAC PIN1 degrader-2 (1) possesses anti-cancer activity, with IC50 values of 2248 nM (MV-4-11 cells), 3984 nM (MOLM-13), 3925 nM (HL-60), 3925 nM (HL-60), 3925 nM (HL-60), 3925 nM (HL-60) and 3925 nM (HL-60) respectively[1].
Applications: Cancer-Kinase/protease
Formula: C40H59ClN6O9S
References: [1]Zhoubing, et al. Compound for degrading Pin1 protein in targeted ubiquitination, and pharmaceutical composition and application thereof. Patent CN116425733A.
CAS Number: 2957895-04-2
Molecular Weight: 835.45
Research Area: Cancer
Target: PIN1;PROTACs