Relutrigine, CAS 2392951-29-8

Product Description: Relutrigine (PRAX-562) is an orally active inhibitor of persistent sodium channel. Relutrigine potently and preferentially inhibits persistent INa induced by ATX-II (Nav 1.5 activator) or the SCN8A mutation N1768D with IC50 values of 141 nM and 75 nM, respectively. Relutrigine exhibits potent use-dependent block and reduces neuronal intrinsic excitability. Relutrigine has effective anticonvulsant activity[1].

Applications: Neuroscience-Neuromodulation

Formula: C15H11F6N5O2

References: [1]Kahlig KM, et al. The novel persistent sodium current inhibitor PRAX-562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers. Epilepsia. 2022 Mar;63(3):697-708.

CAS Number: 2392951-29-8

Molecular Weight: 407.27

Compound Purity: 99.13

Research Area: Neurological Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Sodium Channel

• SKU: MEXHY-148792-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-148792-25
• Package Unit: 25 mg
• Quantity Unit: STK