RIPK1-IN-29

Product Description: RIPK1-IN-29 (Compound 22) is a RIPK1 inhibitor, with an IC50 of 6.9 nM. RIPK1-IN-29 exerts anti-necroptotic (Apoptosis) activity by inhibiting RIPK1. In a TNF-α-induced in vivo inflammation model, at a dose of 10 mg/kg, RIPK1-IN-29 can protect mice from hypothermia and death. RIPK1-IN-29 can be applied to the research field of inflammatory diseases[1].

Formula: C16H17NO3S

References: [1]Ma L, et al. Discovery of phenylisoxazolidine analogs targeting receptor interacting protein kinase 1 with anti-inflammatory activity. Eur J Med Chem. 2025 Jun 5;290:117530.

Molecular Weight: 303.38

Research Area: Inflammation/Immunology

Target: RIP kinase

• SKU: MEXHY-170232-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170232-0
• Package Unit: Get quote
• Quantity Unit: STK