RK-33, CAS 1070773-09-9

RK-33, CAS 1070773-09-9
SKU
CAY20312-10
Packaging Unit
10 mg
Manufacturer
Cayman Chemical

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Shelf life (days): 1460

Info: An inhibitor of DDX3; reduces the helicase activity of Ded1p, the yeast homolog of DDX3, at 50, 100, and 200 nM; reduces the viability of lung cancer cells highly expressing DDX3, including A549, H1299, H23, and H460 cells (IC50s = 4.4-8.4 µM), but not those with low expression of DDX3, such as NCI H3255 cells (IC50 = >25 µM); sensitizes tumors to SABR in a Twist1/KRASG12D-inducible mouse model of lung cancer at 20 mg/kg; reduces SARS-CoV-2 replication, decreases SARS-CoV-2 nsp8 and ORF7a levels, and inhibits apoptosis in SARS-CoV-2-infected Vero E6 cells at 10 µM

Formulation: A crystalline solid

Formal Name: 3,7-dihydro-3,7-bis[(4-methoxyphenyl)methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one

Purity: ≥98%

Formula Markup: C23H20N6O3

Formula Weight: 428.4

CAS Number: 1070773-09-9
More Information
SKU CAY20312-10
Manufacturer Cayman Chemical
Manufacturer SKU 20312-10
Package Unit 10 mg
Quantity Unit STK
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