RO-28-1675, CAS 300353-13-3

Product Description: RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes[1][2].

Applications: Metabolism-sugar/lipid metabolism

Formula: C18H22N2O3S2

References: [1]Joseph Grimsby, et al. Allosteric activators of glucokinase: potential role in diabetes therapy. Science. 2003 Jul 18;301(5631):370-3./[2]Nancy-Ellen Haynes, et al. Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675). J Med Chem. 2010 May 13;53(9):3618-25.

CAS Number: 300353-13-3

Molecular Weight: 378.51

Compound Purity: 99.95

Research Area: Metabolic Disease

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Glucokinase

• SKU: MEXHY-10595-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-10595-50
• Package Unit: 50 mg
• Quantity Unit: STK