(S)-dHTC1, CAS 3081383-46-9

Product Description: (S)-dHTC1 is a molecular glue degrader targeting the transcriptional co-activator ENL. (S)-dHTC1 binds the ligase with high affinity only after forming the ENL:dHTC1 complex with an IC50 value of 93 nM. (S)-dHTC1 degrades ENL in MV4;11 cells with a DC50 value of 26 nM. (S)-dHTC1 can be used for acute myeloid leukemia study[1].

Applications: Cancer-programmed cell death

Formula: C33H40N8O6S

References: [1]JB Shaum, et al. High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity. bioRxiv. September 30, 2024.

CAS Number: 3081383-46-9

Molecular Weight: 676.79

Research Area: Cancer

Target: PROTACs

• SKU: MEXHY-173631-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173631-0
• Package Unit: Get quote
• Quantity Unit: STK