Product Description: SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with an IC50 of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits oxygen consumption rate (OCR), induces reactive oxygen species (ROS) production, and reduces MMP. SCAL-255 can be used in the research of oxidative phosphorylation (OXPHOS)-dependent cancers, such as colorectal cancer (CRC) and acute myeloid leukemia (AML), etc[1].
Applications: Cancer-Kinase/protease
Formula: C27H28F3N5O3
References: [1]Yang Zhou, et al. Synthesis and biological evaluation of novel pyrazole amides as potent mitochondrial complex I inhibitors. Eur J Med Chem. 2023 Oct 5;258:115576.
CAS Number: 2798953-61-2
Molecular Weight: 527.54
Compound Purity: 99.15
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Mitochondrial Metabolism;MMP;Oxidative Phosphorylation;Reactive Oxygen Species
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