Product Description: SCH900776 (MK-8776) is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with an IC50 of 3 nM. SCH900776 shows 50- and 500-fold selectivity over CDK2 and Chk2, respectively[1][2].
Applications: Cancer-Kinase/protease
Formula: C15H18BrN7
References: [1]Montano R, et al. Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites. Mol Cancer Ther. 2012 Feb;11(2):427-38./[2]Guzi TJ, et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10(4):591-602.
CAS Number: 891494-63-6
Molecular Weight: 376.25
Compound Purity: 99.97
Research Area: Cancer
Solubility: DMSO : ≥ 100 mg/mL
Target: Checkpoint Kinase (Chk)
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