SD-436, CAS 2497585-50-7

Product Description: SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC50: 0.5 μM), with IC50 of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma (Pink: STAT3 ligand (HY-169361); Blue: E3 ligase ligand (HY-43722); Black: linker (HY-147052)[1].

Applications: Cancer-programmed cell death

Formula: C58H62F4N9O14PS

References: [1]Xu, et al. Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. Journal of medicinal chemistry. 2024, 67(22), 20495–20513.

CAS Number: 2497585-50-7

Molecular Weight: 1248.20

Target: PROTACs;STAT

• SKU: MEXHY-169360-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-169360-10
• Package Unit: 10 mg
• Quantity Unit: STK