SDUY816

Product Description: SDUY816 is an oral active dual APN/NEP inhibitor, with IC50 values of 0.68 μM for APN and 6.9 μM for NEP. SDUY816 exhibits analgesic effects and demonstrates good safety and pharmacokinetic profiles, with an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral administration, 10 mg/kg). SDUY816 has potential applications in the research of neuropathic pain disorders[1].

Formula: C18H16IN3O3

References: [1]Zhang N, et al. Synthesis and biological evaluation of new dual APN/NEP inhibitors as potent analgesics. Bioorg Chem. 2025 Mar;156:108210.

Molecular Weight: 449.24

Research Area: Neurological Disease

Target: Aminopeptidase;Neprilysin

• SKU: MEXHY-170961-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-170961-0
• Package Unit: Get quote
• Quantity Unit: STK