Product Description: Sematilide (hydrochloride) (Standard) is the analytical standard of Sematilide (hydrochloride). This product is intended for research and analytical applications. Sematilide hydrochloride (CK-1752 hydrochloride) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1].
Formula: C14H24ClN3O3S
References: [1]Ishii Y, et al. Effects of Sematilide, a novel class III antiarrhythmic agent, on membrane currents in rabbit atrial myocytes. Eur J Pharmacol. 1997 Jul 23;331(2-3):295-302./[2]Stanley S. Greenberg, et al. Pharmacology of Sematilide, a non-quaternary class III antiarrhythmic agent.
CAS Number: 101526-62-9
Molecular Weight: 349.88
Research Area: Cardiovascular Disease
Target: Potassium Channel;Reference Standards
English
Deutsch
