SIK2-IN-3, CAS 2810809-10-8

Product Description: SIK2-IN-3 is an orally active SIK1/2 selective inhibitor (IC50: 0.128/0.084 μM). SIK2-IN-3 inhibits CRTC3 phosphorylation and myeloid cell pro-inflammatory cytokine production. SIK2-IN-3 ameliorates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model[1].

Formula: C23H24N6O2

References: [1]Babbe H, et al. Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2307086120.

CAS Number: 2810809-10-8

Molecular Weight: 416.48

Research Area: Inflammation/Immunology

Target: Salt-inducible Kinase (SIK)

• SKU: MEXHY-171590-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-171590-0
• Package Unit: Get quote
• Quantity Unit: STK