SLC7A11-IN-2, CAS 14668-59-8

Product Description: SLC7A11-IN-2 (Compound 1) is an SLC7A11/xCT inhibitor. SLC7A11-IN-2 induces cell death in HeLa cells by lowering intracellular glutathione levels and increasing oxidative stress, thereby disrupting the oxidative balance within the cells, with an IC50 value of 10.23 μM. Molecular dynamics simulation analysis indicates that SLC7A11-IN-2 has a stronger binding affinity to SLC7A11 compared to Erastin (HY-15763). SLC7A11-IN-2 can be utilized in research within the field of cervical cancer[1].

Applications: Cancer-programmed cell death

Formula: C19H24N4O3

References: [1]Yue J, et al. Discovery of the Inhibitor Targeting the SLC7A11/xCT Axis through In Silico and In Vitro Experiments. Int J Mol Sci. 2024 Jul 29;25(15):8284.

CAS Number: 14668-59-8

Molecular Weight: 356.42

Compound Purity: 99.80

Research Area: Cancer

Solubility: DMSO : 175 mg/mL (ultrasonic)

Target: Reactive Oxygen Species

• SKU: MEXHY-169056-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-169056-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK