SMART1

Product Description: SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1. SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer. SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models.(Blue: CRBN ligand; Black: linker; Pink: Smurf1 ligand (Smurf1-L)) [1].

Applications: Cancer-programmed cell death

Formula: C40H35N9O7

References: [1]Peng Z, et al. Targeting Smurf1 to block PDK1-Akt signaling in KRAS-mutated colorectal cancer. Nat Chem Biol. 2024 Jul 22.

Molecular Weight: 753.76

Compound Purity: 99.31

Research Area: Cancer

Target: Akt;PDK-1;PROTACs

• SKU: MEXHY-W998345-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W998345-5
• Package Unit: 5 mg
• Quantity Unit: STK