SNT-8370

Product Description: SNT-8370 is an orally active inhibitor of VAP-1 (IC50: 10 nM) and myeloperoxidase (MPO) (IC50: 17 nM), with >100-1000 fold more potency for VAP-1 and MPO versus other mammalian (per)oxidases. SNT-8370 inhibits MPO-mediated LDL lipid peroxidation. SNT-8370 inhibits leukocyte infiltration in lung injury models of acute inflammation. SNT-8370 is an anti-inflammatory agent, and can be used for research of inflammatory disorders[1].

Applications: COVID-19-immunoregulation

Formula: C16H16FN5O2S

References: [1]Glaros E, et al. Targeting vascular adhesion protein-1 and myeloperoxidase with a dual inhibitor SNT-8370 in preclinical models of inflammatory disease. Nat Commun. 2025 Apr 11;16(1):3430.

Molecular Weight: 361.39

Research Area: Inflammation/Immunology

Target: Glutathione Peroxidase;VAP-1

• SKU: MEXHY-173596-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173596-0
• Package Unit: Get quote
• Quantity Unit: STK