Shelf life (days): 1460
Info: A peptide antagonist of the NK1 receptor (Ki = 177.83 nM); selective for NK1 receptors over NK1 and NK3 receptors (Kis = 5,000 and >10,000 nM, respectively); induces histamine release from isolated rat mast cells (EC50 = 2.5 µM); inhibits neurokinin B-induced contractions in isolated and perfused guinea pig taenia coli when used at a concentration of 10 µM; increases the latency to withdrawal in the tail-flick- or hot plate test but also induces hindlimb paralysis in rats when administered intrathecally at 2 µg/animal; decreases corneal P. aeruginosa levels and polymorphonuclear cell infiltration, reduces corneal Il-1β levels, and increases corneal Il-10 levels in a mouse model of corneal P. aeruginosa infection at 36 µg/animal per day for five days
Formulation: A solid
Formal Name: D-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-leucinamide, trifluoroacetate salt
Amino Acids: rPKPQQwFwLL-NH2
Purity: ≥98%
Formula Markup: C75H108N20O13 • XCF3COOH
Formula Weight: 1497.816
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