Splitomicin (Standard), CAS 5690-03-9

Splitomicin (Standard), CAS 5690-03-9
SKU
MEXHY-100585R-0
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MedChemExpress

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Product Description: Splitomicin (Standard) is the analytical standard of Splitomicin. This product is intended for research and analytical applications. Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD+-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM[1].

Formula: C13H10O2

References: [1]Bedalov A, et al. Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15113-8./[2]Breitenstein A, et al. Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells. Cardiovasc Res. 2011 Feb 1;89(2):464-72./[3]Ota H, et al. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene. 2006 Jan 12;25(2):176-85.

CAS Number: 5690-03-9

Molecular Weight: 198.22

Research Area: Cancer

Target: HDAC;Reference Standards
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SKU MEXHY-100585R-0
Manufacturer MedChemExpress
Manufacturer SKU HY-100585R-0
Package Unit Get quote
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