Product Description: Sulcardine hydrochloride is a multi-ion channel blocker that can reduce INa and ICa with IC50 values of 26.9 µM and 69.2 µM, respectively. Sulcardine hydrochloride is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine hydrochloride has anti-arrhythmic effects[1][2].
Formula: C24H35Cl2N3O4S
References: [1]BaiDL,et al. Discovery ofN-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide(sulcardine) as a novel anti-arrhythmic agent. Acta Pharmacol Sin. 2012Sep;33(9):1176-86./[2]Chen W, et al. Characteristics of hERG and hNav1.5 channel blockade by sulcardine sulfate, a novel anti-arrhythmic compound. Eur J Pharmacol. 2019 Feb 5;844:130-138.
CAS Number: 343935-48-8
Molecular Weight: 532.52
Research Area: Cardiovascular Disease
Target: Calcium Channel;Sodium Channel
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