Product Description: Talotrexin (PT523), an analog of Aminopterin (HY-14518), is a nonpolyglutamatable classic antifolate. Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth[1][2].
Applications: Cancer-programmed cell death
Formula: C27H27N9O6
References: [1]O'Connor C, et al. Folate transporter dynamics and therapy with classic and tumor-targeted antifolates. Sci Rep. 2021 Mar 18;11(1):6389./[2]Choy G S, et al. Combination talotrexin (PT-523) with paclitaxel in A549 non-small cell lung cancer (NSCLC) athymic nude mice xenografts[J]. Cancer Research, 2007, 67(1_Annual_Meeting).
CAS Number: 113857-87-7
Molecular Weight: 573.56
Compound Purity: 99.27
Research Area: Cancer
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: Antifolate;Dihydrofolate reductase (DHFR)
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