Product Description: Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria[1][2].
Applications: COVID-19-immunoregulation
Formula: C19H28BN3O5
Citations: Antimicrob Agents Chemother. 2023 May 31;e0033923./Antimicrob Agents Chemother. 2024 Jan 4:e0133223./Antimicrob Agents Chemother. 2024 Oct 4:e0077524./Engineering. 2024 Apr 12./Int J Antimicrob Agents. 2023 Nov 4:107030./J Antimicrob Chemother. 2023 Mar 15;dkad061./Antimicrob Agents Chemother. 2021 Nov 22;AAC0167621.
References: [1]Krajnc A, et al. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. J Med Chem. 2019 Sep 26;62(18):8544-8556./[2]Liu B ,et al. Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2019 Dec 16.
CAS Number: 1613267-49-4
Molecular Weight: 389.25
Compound Purity: 99.05
Research Area: Infection
Solubility: 10 mM in DMSO
Target: Bacterial;Beta-lactamase
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