Tapotoclax, CAS 1883727-34-1

Product Description: Tapotoclax (AMG-176) is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM[1][2].

Applications: Cancer-programmed cell death

Formula: C33H41ClN2O5S

References: [1]Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies. Cancer Discov. 2018 Sep 25. pii: CD-18-0387./[2]Garner TP, et al. Progress in targeting the BCL-2 family of proteins. Curr Opin Chem Biol. 2017 Aug;39:133-142.

CAS Number: 1883727-34-1

Molecular Weight: 613.21

Compound Purity: 99.53

Research Area: Cancer

Solubility: DMSO : 62.5 mg/mL (ultrasonic)

Target: Bcl-2 Family

• SKU: MEXHY-101565-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-101565-50
• Package Unit: 50 mg
• Quantity Unit: STK