TEC 4

Product Description: TEC 4 is a ByeTAC (Bypassing E-Ligase-Targeting Chimera) BRD4 degrader, with 33% BRD4 remaining at 500 nM in Ramos B-cells. TEC 4 shows toxicity for Ramos B-cells, with an IC50 of 30.5 nM. ByeTACs directly recruits a protein to the proteasome via interactions with Rpn-13 for degradation. Pink: BRD4 lignad (HY-78695); Blue: Rpn-13 ligand (HY-159808); Black: linker (HY-W008352)[1].

Applications: Cancer-programmed cell death

Formula: C48H51BrCl2N10O6S2

References: [1]Loy CA, et al. ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation. J Med Chem. 2025 May 8;68(9):9694-9705.

Molecular Weight: 1078.92

Research Area: Cancer

Target: ByeTAC;Epigenetic Reader Domain

• SKU: MEXHY-176071-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-176071-0
• Package Unit: Get quote
• Quantity Unit: STK