Product Description: Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria[1][2][3]. Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Applications: Neuroscience-Neuromodulation
Formula: C21H26ClN
Citations: Cancer Res. 2022 Sep 2;82(17):3032-3044./Cell Death Dis. 2021 May 13;12(5):482./Adv Healthc Mater. 2023 May 20;e2300018./Adv Sci (Weinh). 2023 Sep;10(27):e2206878./bioRxiv. 2024 May 14./Cancer Commun (Lond). 2021 Jul 16./Clin Transl Med. 2024 Feb;14(2):e1586./Infect Drug Resist. 2022: 7459-7473./Nat Microbiol. 2024 Feb;9(2):346-358./Research Square Preprint. 2023 Sep 26.
References: [1]Ryder NS, et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-8./[2]Mieth H, et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14(2):104-8./[3]Ciftci E, et al. Mupirocin vs terbinafine in impetigo.Indian J Pediatr. 2002 Aug;69(8):679-82.
CAS Number: 78628-80-5
Molecular Weight: 327.89
Compound Purity: 99.86
Research Area: Infection
Solubility: DMSO : 60 mg/mL (ultrasonic)/H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Antibiotic;Bacterial;Fungal
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