Thalidomide-5-NH-PEG1-NH2 (hydrochloride), CAS 2863634-98-2

Product Description: Thalidomide-5-NH-PEG1-NH2 hydrochloride is a Thalidomide (HY-14658)-based cereblon ligand that recruits CRBN proteins. Thalidomide-5-NH-PEG1-NH2 hydrochloride can be connected to the target protein ligand through a linker to form a PROTAC molecule. For example, THAL-SNS-032 (HY-123937).

Applications: Cancer-programmed cell death

Formula: C17H21ClN4O5

References: [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.  [Content Brief]

CAS Number: 2863634-98-2

Molecular Weight: 396.83

Compound Purity: 98.87

Research Area: cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Autophagy;E3 Ligase Ligand-Linker Conjugates

• SKU: MEXHY-156163-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-156163-50
• Package Unit: 50 mg
• Quantity Unit: STK