TIP48/49-IN-1, CAS 1807337-58-1

Product Description: TIP48/49-IN-1 (Compound B) is an orally active and specific inhibitor of RUVBL1/2 ATPase, with an IC50 of 59 nM for purified RUVBL1/2. TIP48/49-IN-1 affects DNA replication process, and leads to S-phase arrest. TIP48/49-IN-1 induces apoptosis. TIP48/49-IN-1 inhibits tumor growth and radiosensitizes non-small cell lung cancer cells (NSCLC)[1].

Formula: C28H30ClN5O4

References: [1]Yenerall P, et al. RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer. Cell Chem Biol. 2020 Jan 16;27(1):105-121.e14.

CAS Number: 1807337-58-1

Molecular Weight: 536.02

Research Area: Cancer

Target: Proton Pump

• SKU: MEXHY-103702-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-103702-0
• Package Unit: Get quote
• Quantity Unit: STK