Product Description: TLR4-IN-2 (Compound Racemic-11k) is inhibitors of TLR4, JNK, and NF-κB. TLR4-IN-2 inhibits NO production in LPS-stimulated RAW264.7 cells with an IC50 value of 23.2 µM. TLR4-IN-2 exerts anti-inflammatory activity by inhibiting TLR4 expression, reducing JNK phosphorylation, thereby suppressing the activation of NF-κB, blocking the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and decreasing the production of inflammatory mediators such as NO, PGE 2, and TNF-α. TLR4-IN-2 is promising for research of inflammatory diseases, such as rheumatoid arthritis and various inflammatory disorders[1].
Applications: COVID-19-immunoregulation
Formula: C23H20O3
References: [1]Tang ML, et al. Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents. Eur J Med Chem. 2016 May 4;113:63-74.
CAS Number: 1019984-44-1
Molecular Weight: 344.40
Research Area: Inflammation/Immunology
Target: COX;JNK;NF-κB;NO Synthase;Toll-like Receptor (TLR)
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