Product Description: TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells[1][2][3].
Applications: Neuroscience-Neuromodulation
Formula: C6H12NO2P
References: [1]Martínez-Torres A, et al. GABArho 1/GABAAalpha 1 receptor chimeras to study receptor desensitization. Proc Natl Acad Sci U S A. 2000;97(7):3562-3566./[2]Graham A. R. Johnston, et al. Neurologically-active compounds. WO1998058939A1/[3]Johnston GA. GABAc receptors: relatively simple transmitter -gated ion channels?. Trends Pharmacol Sci. 1996;17(9):319-323.
CAS Number: 182485-36-5
Molecular Weight: 161.14
Compound Purity: 98.1
Research Area: Neurological Disease
Solubility: H2O : 25 mg/mL (ultrasonic)
Target: GABA Receptor
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