Tri-GalNAc(OAc)3, CAS 1159408-64-6

Tri-GalNAc(OAc)3, CAS 1159408-64-6
SKU
MEXHY-148118-50
Packaging Unit
50 mg
Manufacturer
MedChemExpress

Availability: loading...
Price is loading...
Product Description: Tri-GalNAc(OAc)3is a trivalent N-acetylgalactosamine (GalNAc) derivative that can be used to synthesize GalNAc-LYTAC. Tri-GalNAc is a specific ligand targeting the asialoglycoprotein receptor (ASGPR), mediating the endocytosis and transport of cell surface proteins (such as EGFR, HER2) to lysosomes for degradation by lysosomal targeting chimeras (LYTACs). Tri-GalNAc significantly reduces the level of target proteins and inhibits downstream signaling pathways (such as EGFR-mediated Akt and MAPK signals). Tri-GalNAc(OAc)3can be used for hepatocyte targeting studies, and can degrade carcinogenic membrane proteins and inhibit tumor cell proliferation in liver cancer cell models[1].

Applications: Cancer-programmed cell death

Formula: C79H128N10O36

References: [1]Ahn G, et al. LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation. Nat Chem Biol. 2021 Sep;17(9):937-946.

CAS Number: 1159408-64-6

Molecular Weight: 1793.91

Compound Purity: 98.09

Research Area: Cancer

Solubility: DMSO : 10 mg/mL (ultrasonic)

Target: LYTACs
More Information
SKU MEXHY-148118-50
Manufacturer MedChemExpress
Manufacturer SKU HY-148118-50
Package Unit 50 mg
Quantity Unit STK
Product information (PDF)
×
MSDS (PDF)
×