Product Description: TRPC3/6-IN-1 is a potent selectivity blocker of the canonical transient receptor channels (TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure[1].
Applications: Neuroscience-Neuromodulation
Formula: C20H19N3O2S
References: [1]David G Washburn, et al. The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4979-84.
CAS Number: 736945-96-3
Molecular Weight: 365.45
Research Area: Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: TRP Channel