Product Description: TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arrest and apoptosis, decreases the migration of MCF-7 and BGC-823 cells. TRPM7-IN-1 decreases vimentin expression and increases E-cadherin expression. TRPM7-IN-1 potentially reduces the TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway. TRPM7-IN-1 is a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function[1].
Formula: C23H25N5O3
References: [1]Xiaoding Zhang, et al. Novel benzoylurea derivative decreases TRPM7 channel function and inhibits cancer cells migration. Channels (Austin). 2024 Dec;18(1):2396339.
CAS Number: 1909225-07-5
Molecular Weight: 419.48
Research Area: Cancer
Target: Akt;Apoptosis;PI3K;TRP Channel
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