Product Description: TRPV1-IN-3 (compound 14) is a TRPV1 inhibitor that can be used for the research of idiopathic pulmonary fibrosis. TRPV1-IN-3 affects the expression of fibrosis markers collagen I and α-SMA by inhibiting the TGF-β/Smads and MAPK pathways, thereby exerting antifibrotic activity in vitro (IC50=0.51 μM). TRPV1-IN-3 significantly inhibits collagen deposition in lung tissue, improves the alveolar structure, and also increases the survival rate of mice with pulmonary fibrosis induced by Bleomycin (HY-108345)[1].
Applications: COVID-19-immunoregulation
Formula: C19H20O3
References: [1]Cao Y, et al. Discovery of novel capsaicin analogs as TRPV1 inhibitors for the treatment of idiopathic pulmonary fibrosis. Eur J Med Chem. 2025 Feb 15;284:117229.
CAS Number: 87657-67-8
Molecular Weight: 296.36
Research Area: Inflammation/Immunology
Target: TRP Channel
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