TrxR-IN-8, CAS 2857180-28-8

Product Description: TrxR-IN-8 (Compound 6f) is a selective TrxR inhibitor (IC50: 10.2 μM). TrxR-IN-8 induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species (ROS), reducing intracellular thiols, and lowering the glutathione/glutathione ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells[1].

Applications: Cancer-programmed cell death

Formula: C16H16INO2

References: [1]Xu Q, et al. Structural simplification of quaternary benzophenanthridine alkaloids generating a candidate for the treatment of non-small cell lung cancer. Eur J Med Chem. 2025 Jun 5;290:117551.

CAS Number: 2857180-28-8

Molecular Weight: 381.21

Research Area: Cancer

Target: Apoptosis;Reactive Oxygen Species;TrxR

• SKU: MEXHY-173403-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-173403-0
• Package Unit: Get quote
• Quantity Unit: STK