Tubulin inhibitor 35, CAS 2247047-77-2

Product Description: Tubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I (IC50=~50 μM) and tubulin polymerization (IC50=5.69 μM). Tubulin inhibitor 35 inhibits migration and invasion of MGC-803 and RKO cell lines，and induces apoptosis via arresting cell cycle at G2/M phase. Tubulin inhibitor 35 exhibis potent efficacy in gastrointestinal tumor inhibiton (inhibits MGC-803 (IC50=0.09 μM) and RKO (IC50=0.2 μM) cell lines)[1].

Applications: Cancer-programmed cell death

Formula: C21H21N3O

References: [1]Deng J, et al. N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubulin-Inhibiting anti-gastrointestinal tumor agents. Eur J Med Chem. 2023 Jul 5;255:115366.

CAS Number: 2247047-77-2

Molecular Weight: 331.41

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Microtubule/Tubulin

• SKU: MEXHY-155073-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-155073-5
• Package Unit: 5 mg
• Quantity Unit: STK