Tubulin/MMP-IN-3

Product Description: Tubulin/MMP-IN-3 (Compound 15j) is the dual inhibitor for tubulin polymerization and MMP, and inhibits MMP-2 and MMP-9 with IC50 of 21.13 μM and 19.24 μM. Tubulin/MMP-IN-3 inhibits NF-κB signaling pathway, causes mitochondrial dysfunction and the apoptosis through a mitochondrial-dependent pathway. Tubulin/MMP-IN-3 exhibits antiproliferative activity in a variety of cancer cells, arrests the cell cycle at G2/M phase, and exhibits antitumor efficacy in mouse models[1].

Applications: Cancer-Kinase/protease

Formula: C38H41N2O12P

References: [1]Li G, et al., Discovery of novel dual tubulin and MMPs inhibitors for the treatment of lung cancer and overcoming drug resistance. Eur J Med Chem. 2025 Jan 9;285:117249.

Molecular Weight: 748.71

Research Area: Cancer

Target: Apoptosis;Microtubule/Tubulin;MMP;NF-κB

• SKU: MEXHY-172088-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-172088-0
• Package Unit: Get quote
• Quantity Unit: STK