VAV1 degrader-3, CAS 3050683-38-7

Product Description: VAV1 degrader-3 (Example 185) is an orally active VAV1 molecular glue degrader (DC50: 7 nM). VAV1 degrader-3 reduces immune cell activation, immune cell proliferation and the production of various cytokines. VAV1 degrader-3 can be used for research of inflammatory or autoimmune disorder. VAV1 degrader-3 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc.[1].

Applications: COVID-19-immunoregulation

Formula: C22H17ClN2O3

References: [1]Laura Ann Mcallister, et al. Targeted degradation of vav1. Patent. WO2024151547A1.

CAS Number: 3050683-38-7

Molecular Weight: 392.83

Compound Purity: 99.26

Research Area: Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Molecular Glues

• SKU: MEXHY-168625-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-168625-50
• Package Unit: 50 mg
• Quantity Unit: STK