Product Description: Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker. IC50 for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channelwt, Kv1.5 channelI508F, Kv1.5 channelT479A, respectively.
Applications: COVID-19-immunoregulation
Formula: C20H32ClNO4
References: [1]Eldstrom J, et al. The molecular basis of high-affinity binding of the antiarrhythmic compound Vernakalant (RSD1235) to Kv1.5 channels. Mol Pharmacol. 2007 Dec;72(6):1522-34./[2]Chiba T, et al. Influences of rapid pacing-induced electrical remodeling on pharmacological manipulation of the atrial refractoriness in rabbits. J Pharmacol Sci. 2016 Mar;130(3):170-6.
CAS Number: 748810-28-8
Molecular Weight: 385.93
Compound Purity: 99.33
Research Area: Cardiovascular Disease
Solubility: DMSO : 50 mg/mL (ultrasonic)/H2O : 50 mg/mL (ultrasonic)
Target: Potassium Channel
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