VU0546110, CAS 1421523-00-3

Product Description: VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, with IC50s of 1.287 μM (SLO3) and 59.80 μM (SLO1) in HEK293 cells, respectively. VU0546110 blocks heterologous SLO3 currents and endogenous K+ currents in human sperm. VU0546110 halts sperm hyperpolarization, induced acrosome reaction, and hyper-activated motility. VU0546110 has contraceptive potential[1].

Formula: C24H31NO4S2

References: [1]Lyon M, et al. A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function. Proceedings of the National Academy of Sciences of the United States of America. 2023, 120(4), e2212338120.

CAS Number: 1421523-00-3

Molecular Weight: 461.64

Compound Purity: 97.05

Research Area: Endocrinology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Potassium Channel

• SKU: MEXHY-164911-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-164911-50
• Package Unit: 50 mg
• Quantity Unit: STK