W-54011, CAS 405098-33-1

Product Description: W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC50s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively[1].

Formula: C30H37ClN2O2

References: [1]Sumichika H, et al. Identification of a potent and orally active non-peptide C5a receptor antagonist. J Biol Chem. 2002 Dec 20;277(51):49403-49407.

CAS Number: 405098-33-1

Molecular Weight: 493.08

Compound Purity: 98.0

Research Area: Inflammation/Immunology

Solubility: DMSO : ≥ 28 mg/mL

Target: Complement System;Reactive Oxygen Species

• SKU: MEXHY-16992A-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-16992A-25
• Package Unit: 25 mg
• Quantity Unit: STK