WDR5-MYC Probe 12

Formulation: A solid

Formal Name: 3',5'-difluoro-4'-((6-methyl-4-oxo-1-phenyl-1,4-dihydropyridazine-3-carboxamido)methyl)-[1,1'-biphenyl]-3-sulfonyl fluoride

Purity: ≥98%

Formula Markup: C25H18F3N3O4S

Formula Weight: 513,5

Shelf life (days): 1095

Notes: WDR5-MYC probe 12 is an inhibitor of the protein-protein interaction between the master transcription factor Myc and WD repeat domain 5 (WDR5; IC50 = 0.39 µM).{72194} It reduces mRNA expression of the Myc and WDR5 co-binding target genes ribosomal protein L17 (RPL17), RPL23, RPL35, and RPL37A in HL-60 cells. WDR5-MYC probe 12 also inhibits the growth of HL-60, NB4, Ramos (RA 1), COR-L279, and NCI H520 cancer cells (GI50s = 4.2-9.4 µM).

• SKU: CAY39304-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39304-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK